Electrical Stimulation Reduces Age Related Atrophy and Weakness in Edl Muscles of Rats
نویسنده
چکیده
Skeletal muscles atrophy and weaken with old age. The number of motor-units decreases and the number of denervated fibres increases with age. Denervated fibres lack contractile activity, atrophy, and contribute to whole muscle atrophy and weakness. Electrical stimulation of denervated muscles suppresses the atrophy and weakness. We electrically stimulated EDL muscles of adult and old rats during a 2 month period of denervation. The control muscles of old rats had declines in muscle mass and maximum force compared with adult control muscles. Denervated muscles of either adult or old rats had even larger declines. Stimulateddenervated muscles of adult rats maintained mass and force at values not different from adult control values. Stimulated-denervated muscles of old rats maintained mass and force at values not lower than control muscles of old rats, and mass was even maintained not different from adult control values.
منابع مشابه
Electrical stimulation attenuates denervation and age-related atrophy in extensor digitorum longus muscles of old rats.
Skeletal muscles of old rats and elderly humans lose muscle mass and maximum force. Denervation is a major cause of age-related muscle atrophy and weakness, because denervated fibers do not contract, and undergo atrophy. At any age, surgical denervation causes even more dramatic muscle atrophy and loss in force than aging does. Electrical stimulation that generates tetanic contractions of dener...
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